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An ankylosing spondylitis risk variant alters osteoclast differentiation.
Wu F, Han X, Liu J, Zhang Z, Yan K, Wang B, Yang L, Zou H, Yang C, Huang W, Jin L, Wang J, Qian F, Niu Z. Wu F, et al. Rheumatology (Oxford). 2023 May 2;62(5):1980-1987. doi: 10.1093/rheumatology/keac542. Rheumatology (Oxford). 2023. PMID: 36124946
We also discovered that PSMB1 regulates the receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) signalling pathway and the disease-associated variant PSMB1-Pro11 significantly inhibits RANKL-induced NF-kappaB pathway in osteoclast differentiation …
We also discovered that PSMB1 regulates the receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) signalling pathway …
Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine.
van den Biggelaar RHGA, van der Maas L, Meiring HD, Pennings JLA, van Eden W, Rutten VPMG, Jansen CA. van den Biggelaar RHGA, et al. Sci Rep. 2021 Jun 16;11(1):12666. doi: 10.1038/s41598-021-89810-3. Sci Rep. 2021. PMID: 34135356 Free PMC article.
Markers that showed increased expression at both mRNA and protein levels included PLIN2 and PSMB1. Stimulation with infectious bronchitis virus only resulted in 25 differentially expressed proteins, which were mostly proteins containing Src homology 2 domains. ...This stud …
Markers that showed increased expression at both mRNA and protein levels included PLIN2 and PSMB1. Stimulation with infectious bronch …
Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma.
Walter RFH, Sydow SR, Berg E, Kollmeier J, Christoph DC, Christoph S, Eberhardt WEE, Mairinger T, Wohlschlaeger J, Schmid KW, Mairinger FD. Walter RFH, et al. Cancer Manag Res. 2019 Sep 24;11:8711-8720. doi: 10.2147/CMAR.S194337. eCollection 2019. Cancer Manag Res. 2019. PMID: 31576173 Free PMC article.
METHODS: 171 patients with MPM were analyzed for their mRNA expression of proteasomal subunits PSMA1, PSMA5, PSMB1, PSMB2, PSMB4 and PSMB5 via qPCR (n=84) or sequencing (n=87 TCGA/cBioPortal data set "Mesothelioma"). ...
METHODS: 171 patients with MPM were analyzed for their mRNA expression of proteasomal subunits PSMA1, PSMA5, PSMB1, PSMB2, PSMB4 and …
Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion.
Lu L, Song HF, Zhang WG, Liu XQ, Zhu Q, Cheng XL, Yang GJ, Li A, Xiao ZC. Lu L, et al. Biochem Biophys Res Commun. 2012 May 25;422(1):121-7. doi: 10.1016/j.bbrc.2012.04.119. Epub 2012 Apr 30. Biochem Biophys Res Commun. 2012. PMID: 22564728
Human bone marrow stromal cells (hBMSCs) could be used in clinics as precursors of multiple cell lineages following proper induction. ...Consistent with prior reports, long-term in vitro expansion of hBMSCs decreased cell proliferation and increased replicative senescence, …
Human bone marrow stromal cells (hBMSCs) could be used in clinics as precursors of multiple cell lineages following proper induction. …